MSX-Mbox 4.5
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http://www.msxposse.com
  
This programs contains 544 single games and 135 Maniadisks (more than 1200 rom and dsk games) for MSX, which you can play in a very simple way. Just select the game and press the run button.

You can choose between four emulators:

FMSX-DOS (version 1.6b2.a)
FMSX-SDL (version 2.6.0.40)
NLMSX (version 0.48)
BlueMSX (version 2.0)